Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1039781 | 0.87 | HPGD (0.51) | HPGDALDH1A1SMN1; SMN2MAPTHTT | |
| SCHEMBL1038002 | 0.84 | MEN1 (0.48) | HPGDALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL8337800 | 0.84 | PTGER1 (0.62) | HPGDSMN1; SMN2MAPTPTGER1TP53 | |
| SCHEMBL1040791 | 0.80 | TEAD1 (0.54) | HPGDALDH1A1SMN1; SMN2TP53MEN1 | |
| SCHEMBL1038744 | 0.79 | HPGD (0.48) | HPGDALDH1A1POLBMEN1KMT2A | |
| SCHEMBL8337782 | 0.77 | HPGD (0.74) | HPGDALDH1A1SMN1; SMN2MAPTPTGER1 | |
| SCHEMBL1039430 | 0.76 | HCRTR2 (0.54) | HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL8337250 | 0.74 | PTGER1 (0.58) | HPGDALDH1A1SMN1; SMN2MAPTPTGER1 | |
| SCHEMBL12956486 | 0.72 | HSD17B10 (0.46) | HPGDALDH1A1SMN1; SMN2PTGER1TP53 | |
| SCHEMBL18102008 | 0.71 | MAPT (0.71) | HPGDALDH1A1SMN1; SMN2MAPTPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004033418-A2 | SULFONYLAMINO-ACETIC DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2004-04-22 | — | — | WO | disclosed |