Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1040894 | 0.83 | HCRTR2 (0.62) | MEN1KMT2AESR1KEAP1NFE2L2 | |
| SCHEMBL8337800 | 0.81 | PTGER1 (0.62) | PTGER1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL1039017 | 0.79 | TEAD1 (0.55) | MAPTSMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL1038651 | 0.76 | L3MBTL1 (0.47) | MAPTSMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL16557468 | 0.75 | HPGD (0.81) | MAPTSMN1; SMN2TP53ALDH1A1HPGD | |
| SCHEMBL8337641 | 0.74 | HPGD (0.55) | PTGER1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL18101489 | 0.73 | SMN1; SMN2 (0.70) | MAPTSMN1; SMN2TP53ALDH1A1HPGD | |
| SCHEMBL12956486 | 0.73 | HSD17B10 (0.46) | PTGER1SMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL8338556 | 0.73 | PTGER1 (0.55) | PTGER1MAPTSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL2174816 | 0.72 | SMN1; SMN2 (0.57) | PTGER1MAPTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004033418-A2 | SULFONYLAMINO-ACETIC DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2004-04-22 | — | — | WO | disclosed |