Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 7/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | GCGR | P47871 | 4/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | GIPR | P48546 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873269 | 1.00 | MMP12 (0.57) | MMP12MMP13TRPV1PTGESCHRM2 | |
| SCHEMBL6873265 | 1.00 | MMP12 (0.57) | MMP12MMP13TRPV1PTGESCHRM2 | |
| SCHEMBL6532657 | 0.92 | MMP12 (0.58) | MMP12MMP13TRPV1PTGESCHRM2 | |
| SCHEMBL6885140 | 0.92 | MMP12 (0.58) | MMP12MMP13TRPV1PTGESCHRM2 | |
| SCHEMBL8342675 | 0.92 | MMP12 (0.58) | MMP12MMP13TRPV1PTGESCHRM2 | |
| SCHEMBL6882759 | 0.91 | MMP12 (0.53) | MMP12MMP13TRPV1PTGESCHRM2 | |
| SCHEMBL6882754 | 0.91 | MMP12 (0.53) | MMP12MMP13TRPV1PTGESCHRM2 | |
| SCHEMBL6530340 | 0.91 | MMP12 (0.63) | MMP12MMP13TRPV1CHRM2CHRM1 | |
| SCHEMBL6882944 | 0.91 | MMP12 (0.63) | MMP12MMP13TRPV1CHRM2CHRM1 | |
| SCHEMBL6875032 | 0.86 | MMP12 (0.54) | MMP12MMP13TRPV1PTGESABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004018448-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2004-03-04 | — | — | WO | disclosed |