SCHEMBL8338931

SCHEMBL8338931

CN1CC[C@@H](Oc2cc(NS(=O)(=O)c3cc(-c4ccccc4Cl)c(Cl)s3)ccc2C(F)(F)F)C1

nearest known ligand 0.57

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 18/20 0.57
USP1 O94782 1/20 0.36
USP8 P40818 1/20 0.36
OTUB1 Q96FW1 1/20 0.36
USP36 Q9P275 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6826104 0.94 UTS2R (0.57) UTS2R
SCHEMBL6826102 0.94 UTS2R (0.57) UTS2R
SCHEMBL8338633 0.92 UTS2R (0.62) UTS2R
SCHEMBL6828746 0.92 UTS2R (0.55) UTS2R
SCHEMBL6828751 0.92 UTS2R (0.55) UTS2R
SCHEMBL6828983 0.91 UTS2R (0.56) UTS2R
SCHEMBL6828977 0.91 UTS2R (0.56) UTS2R
SCHEMBL6828863 0.90 UTS2R (0.52) UTS2RUSP1USP8OTUB1USP36
SCHEMBL6828865 0.90 UTS2R (0.52) UTS2RUSP1USP8OTUB1USP36
SCHEMBL6828353 0.89 UTS2R (0.63) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043368-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed