SCHEMBL8338940

SCHEMBL8338940

COc1ccc(Cl)cc1-c1cc(S(=O)(=O)Nc2ccc(C(F)(F)F)c(O[C@@H]3CCN(C)C3)c2)sc1Cl

nearest known ligand 0.62

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 18/20 0.62
SMN1; SMN2 Q16637 1/20 0.39
HTR6 P50406 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8338633 0.92 UTS2R (0.62) UTS2R
SCHEMBL6828977 0.91 UTS2R (0.56) UTS2R
SCHEMBL6828983 0.91 UTS2R (0.56) UTS2R
SCHEMBL6828687 0.90 UTS2R (0.61) UTS2R
SCHEMBL6828685 0.90 UTS2R (0.61) UTS2R
SCHEMBL6828891 0.90 UTS2R (0.57) UTS2RHTR6
SCHEMBL6828887 0.90 UTS2R (0.57) UTS2RHTR6
SCHEMBL6826102 0.88 UTS2R (0.57) UTS2RHTR6
SCHEMBL6828702 0.88 UTS2R (0.57) UTS2RHTR6
SCHEMBL6826104 0.88 UTS2R (0.57) UTS2RHTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043368-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed