SCHEMBL6828685

SCHEMBL6828685

COc1ccc(Cl)cc1-c1sc(S(=O)(=O)Nc2ccc(C(F)(F)F)c(O[C@@H]3CCN(C)C3)c2)cc1Cl

nearest known ligand 0.61

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 19/20 0.61
FPR2 P25090 1/20 0.39
PROKR1 Q8TCW9 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6828687 1.00 UTS2R (0.61) UTS2RFPR2PROKR1
SCHEMBL6828755 0.92 UTS2R (0.61) UTS2R
SCHEMBL6828760 0.92 UTS2R (0.61) UTS2R
SCHEMBL8338940 0.90 UTS2R (0.62) UTS2R
SCHEMBL8338054 0.88 UTS2R (0.57) UTS2R
SCHEMBL6828358 0.88 UTS2R (0.59) UTS2R
SCHEMBL6825905 0.88 UTS2R (0.59) UTS2R
SCHEMBL6828435 0.88 UTS2R (0.59) UTS2R
SCHEMBL6828437 0.88 UTS2R (0.59) UTS2R
SCHEMBL6828931 0.88 UTS2R (0.56) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043368-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO claimed
WO-2004043368-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed