Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16397715 | 0.75 | — | — | |
| SCHEMBL7511152 | 0.69 | BACE1 (0.33) | BACE1 | |
| SCHEMBL4554169 | 0.65 | — | — | |
| SCHEMBL11622748 | 0.64 | — | — | |
| SCHEMBL30961504 | 0.64 | CRBN (0.32) | — | |
| SCHEMBL123776 | 0.63 | TDP1 (0.33) | TDP1 | |
| SCHEMBL7986251 | 0.62 | CRBN (0.33) | TDP1 | |
| SCHEMBL30995351 | 0.61 | TDP1 (0.32) | TDP1 | |
| SCHEMBL11012786 | 0.60 | — | — | |
| SCHEMBL5257847 | 0.59 | GSK3A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114149423-B | Tetrahydropyridopyrimidinedione derivative, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2023-12-12 | — | — | CN | disclosed |
| CN-114149423-B | Tetrahydropyridopyrimidinedione derivative, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2023-12-12 | — | — | CN | disclosed |
| CN-114456163-B | Tetrahydropyridopyrimidinedione derivative, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2023-08-11 | — | — | CN | disclosed |
| CN-114456163-B | Tetrahydropyridopyrimidinedione derivative, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2023-08-11 | — | — | CN | disclosed |
| CN-114456163-A | Tetrahydropyridopyrimidine diketone derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114456163-A | Tetrahydropyridopyrimidine diketone derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114149423-A | Tetrahydropyridopyrimidine diketone derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-03-08 | — | — | CN | disclosed |
| CN-114149423-A | Tetrahydropyridopyrimidine diketone derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-03-08 | — | — | CN | disclosed |
| US-5919778-A | Cyclic amide derivatives | EISAI CO., LTD. (JP) | 1999-07-06 | — | — | US | disclosed |
| US-5654308-A | PREVENT OR TREAT DISEASE DUE TO INSUFFICIENT CHOLINE FUNCTION | EISAI CO., LTD. (JP) | 1997-08-05 | — | — | US | disclosed |
| US-5620976-A | PREVENTION AND TREATMENT OF DISEASES DUE TO INSUFFICIENCY OF THE CENTRAL CHOLINE FUNCTIONS | EISAI CO., LTD. (JP) | 1997-04-15 | — | — | US | disclosed |
| EP-0742216-A2 | Cyclic amide derivatives | Eisai Co., Ltd. (JP) | 1996-11-13 | — | — | EP | disclosed |
| US-5521182-A | ACETYLCHOLINESTERASE INHIBITORS | EISAI CO., LTD. (JP) | 1996-05-28 | — | — | US | disclosed |
| US-5504088-A | ACETYLCHOLINE ESTERASE INHIBITORS; ALZHEIMER'S DISEASE AND OTHER DISEASES CAUSED BY A LOW CONCENTRATION OF CHOLINE | EISAI CO., LTD. (JP) | 1996-04-02 | — | — | US | disclosed |
| US-5292735-A | Cyclic amide derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| EP-0468187-A2 | Cyclic amide derivatives | Eisai Co., Ltd. (JP) | 1992-01-29 | — | — | EP | disclosed |