Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SCN1A | P35498 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DUT | P33316 | 4/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8336619 | 1.00 | LMNA (0.56) | LMNAATML3MBTL1HRH1MEN1 | |
| SCHEMBL8336623 | 1.00 | LMNA (0.56) | LMNAATML3MBTL1HRH1MEN1 | |
| SCHEMBL10123845 | 0.95 | LMNA (0.51) | LMNAATML3MBTL1HRH1MEN1 | |
| SCHEMBL8342637 | 0.88 | LMNA (0.53) | LMNAATML3MBTL1HRH1CHRM3 | |
| SCHEMBL8339348 | 0.88 | LMNA (0.53) | LMNAATML3MBTL1HRH1CHRM3 | |
| SCHEMBL8343216 | 0.88 | LMNA (0.53) | LMNAATML3MBTL1HRH1CHRM3 | |
| SCHEMBL8477474 | 0.85 | LMNA (0.51) | LMNAATML3MBTL1HRH1CHRM3 | |
| SCHEMBL8477470 | 0.85 | LMNA (0.51) | LMNAATML3MBTL1HRH1CHRM3 | |
| SCHEMBL8481946 | 0.85 | LMNA (0.51) | LMNAATML3MBTL1HRH1CHRM3 | |
| SCHEMBL20600129 | 0.84 | ATM (0.51) | LMNAATML3MBTL1HRH1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925666-A | DOPAMINE UPTAKE INHIBITORS; DRUG ABUSE AND DEPENDENCE, EATING DISORDERS, ATTENTION DEFICIT DISORDER, TOURETTE*S SYNDROME, GAMBLING | GUILFORD PHARMACEUTICALS INC. (US) | 1999-07-20 | — | — | US | claimed |
| WO-1999003467-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING COMPULSIVE DISORDERS USING PYRROLIDINE DERIVATIVES | GUILFORD PHARMACEUTICALS INC. (US) | 1999-01-28 | — | — | WO | claimed |
| US-5925666-A | DOPAMINE UPTAKE INHIBITORS; DRUG ABUSE AND DEPENDENCE, EATING DISORDERS, ATTENTION DEFICIT DISORDER, TOURETTE*S SYNDROME, GAMBLING | GUILFORD PHARMACEUTICALS INC. (US) | 1999-07-20 | — | — | US | disclosed |
| WO-1999003467-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING COMPULSIVE DISORDERS USING PYRROLIDINE DERIVATIVES | GUILFORD PHARMACEUTICALS INC. (US) | 1999-01-28 | — | — | WO | disclosed |
| US-5650521-A | FOR TREATING COCAINE ADDICTION AND OVERDOSE, AND DISEASES AND CONDITIONS CHARACTERIZED BY ABNORNAL DOPAMINERGIC NEUROTRANSMISSION | GUILFORD PHARMACEUTICALS INC. (US) | 1997-07-22 | — | — | US | disclosed |