SCHEMBL8339676

SCHEMBL8339676

COc1cccc(Sc2ccc(S(=O)(=O)Nc3ccc(C(F)(F)F)c(O[C@@H]4CCN(C)C4)c3)s2)c1

nearest known ligand 0.59

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 17/20 0.59
LMNA P02545 2/20 0.41
MEN1 O00255 1/20 0.41
PKM P14618 1/20 0.41
KMT2A Q03164 1/20 0.41
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8339147 0.89 UTS2R (0.65) UTS2RLMNAHTTSMN1; SMN2
SCHEMBL8339021 0.89 UTS2R (0.57) UTS2RLMNASMN1; SMN2
SCHEMBL6820771 0.89 UTS2R (0.63) UTS2RLMNAMEN1PKMKMT2A
SCHEMBL6820769 0.89 UTS2R (0.63) UTS2RLMNAMEN1PKMKMT2A
SCHEMBL6823730 0.88 UTS2R (0.58) UTS2RLMNAHTTSMN1; SMN2
SCHEMBL6823733 0.88 UTS2R (0.58) UTS2RLMNAHTTSMN1; SMN2
SCHEMBL8339024 0.87 UTS2R (0.59) UTS2RSMN1; SMN2
SCHEMBL6820424 0.87 UTS2R (0.59) UTS2RSMN1; SMN2
SCHEMBL6820413 0.87 UTS2R (0.59) UTS2RSMN1; SMN2
SCHEMBL6817515 0.86 UTS2R (0.57) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043917-A1 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed