SCHEMBL8339703

SCHEMBL8339703

Cc1ccc(Sc2ccc(S(=O)(=O)Nc3ccc(C(F)(F)F)c(O[C@@H]4CCN(C)C4)c3)cc2)cc1C

nearest known ligand 0.61

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 16/20 0.61
CASP6 P55212 1/20 0.46
GFER P55789 1/20 0.46
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
PKM P14618 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6824514 0.91 UTS2R (0.64) UTS2R
SCHEMBL6821079 0.91 UTS2R (0.64) UTS2RMEN1KMT2A
SCHEMBL6821074 0.91 UTS2R (0.64) UTS2RMEN1KMT2A
SCHEMBL6824508 0.91 UTS2R (0.64) UTS2R
SCHEMBL6823786 0.89 UTS2R (0.70) UTS2RMEN1KMT2A
SCHEMBL6821116 0.89 UTS2R (0.61) UTS2R
SCHEMBL6823624 0.89 UTS2R (0.61) UTS2R
SCHEMBL6823631 0.89 UTS2R (0.61) UTS2R
SCHEMBL6823780 0.89 UTS2R (0.70) UTS2RMEN1KMT2A
SCHEMBL6821111 0.89 UTS2R (0.61) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043917-A1 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed