Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8340421 | 0.94 | CYP3A4 (0.34) | CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8340205 | 0.93 | CYP3A4 (0.34) | CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8338232 | 0.92 | CYP3A4 (0.33) | CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8339873 | 0.92 | CYP3A4 (0.33) | CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8336641 | 0.92 | CYP3A4 (0.33) | CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8339670 | 0.91 | MEN1 (0.31) | CYP3A4CYP2D6CYP2C9MEN1MAPK1 | |
| SCHEMBL8340145 | 0.86 | GAA (0.39) | MEN1HTTKMT2A | |
| SCHEMBL8341149 | 0.84 | KMT2A (0.34) | MEN1MAPK1HTTKMT2A | |
| SCHEMBL8339030 | 0.81 | MEN1 (0.32) | MEN1MAPK1HTTKMT2A | |
| SCHEMBL8338867 | 0.81 | KMT2A (0.30) | MEN1MAPK1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |