Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | PPARG | P37231 | 5/20 | 0.45 |
| ▸ | PPARA | Q07869 | 5/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.42 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.42 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8340510 | 1.00 | MAPT (0.46) | MAPTPPARGPPARAFFAR1KDR | |
| SCHEMBL6587031 | 0.88 | PPARG (0.51) | MAPTPPARGPPARAFFAR1KDR | |
| SCHEMBL6587033 | 0.88 | PPARG (0.51) | MAPTPPARGPPARAFFAR1KDR | |
| SCHEMBL6584122 | 0.87 | MAPT (0.52) | MAPTPPARGPPARAFFAR1KDR | |
| SCHEMBL6584125 | 0.87 | MAPT (0.52) | MAPTPPARGPPARAFFAR1KDR | |
| SCHEMBL8337350 | 0.85 | KDR (0.45) | MAPTPPARGPPARAFFAR1KDR | |
| SCHEMBL8340640 | 0.85 | KDR (0.49) | MAPTPPARGPPARAFFAR1KDR | |
| SCHEMBL6972047 | 0.85 | KDR (0.49) | MAPTPPARGPPARAFFAR1KDR | |
| SCHEMBL8337351 | 0.85 | KDR (0.45) | MAPTPPARGPPARAFFAR1KDR | |
| SCHEMBL8524584 | 0.79 | FFAR1 (0.49) | MAPTPPARGPPARAFFAR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965589-A | AN ACTIVE MATERIAL HAVING HYPOGLYCEMIC ACTIVITY AND BLOOD LIPID LOWERING ACTIVITY, FOR USE AS AN ANTIDIABETIC AGENT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-12 | — | — | US | disclosed |
| EP-0783496-A1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996005186-A1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-02-22 | — | — | WO | disclosed |