SCHEMBL6587033

SCHEMBL6587033

COC(=O)C=Cc1ccc(OCc2nc(-c3ccccc3)oc2C)c(F)c1

nearest known ligand 0.51

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PPARG P37231 5/20 0.51
PPARA Q07869 5/20 0.51
TP53 P04637 3/20 0.49
POLB P06746 1/20 0.48
MAPT P10636 4/20 0.47
FFAR1 O14842 2/20 0.47
PPARD Q03181 2/20 0.47
KDR P35968 1/20 0.46
KDM4E B2RXH2 1/20 0.45
IP6K1 Q92551 1/20 0.44
IP6K3 Q96PC2 1/20 0.44
IP6K2 Q9UHH9 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6587031 1.00 PPARG (0.51) PPARGPPARATP53POLBMAPT
SCHEMBL8524587 0.91 FFAR1 (0.49) PPARGPPARATP53POLBMAPT
SCHEMBL8524584 0.91 FFAR1 (0.49) PPARGPPARATP53POLBMAPT
SCHEMBL6584125 0.90 MAPT (0.52) PPARGPPARATP53POLBMAPT
SCHEMBL6584122 0.90 MAPT (0.52) PPARGPPARATP53POLBMAPT
SCHEMBL8340510 0.88 MAPT (0.46) PPARGPPARATP53POLBMAPT
SCHEMBL8340506 0.88 MAPT (0.46) PPARGPPARATP53POLBMAPT
SCHEMBL6584029 0.84 KDR (0.47) PPARGPPARATP53POLBMAPT
SCHEMBL6584026 0.84 KDR (0.47) PPARGPPARATP53POLBMAPT
SCHEMBL8337476 0.84 PPARG (0.49) PPARGPPARATP53POLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0710659-B1 Oxazolidinedione derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2004-01-28 EP disclosed
EP-0783496-B9 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-09-03 EP disclosed
EP-0783496-B1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-03-26 EP disclosed
US-5965589-A AN ACTIVE MATERIAL HAVING HYPOGLYCEMIC ACTIVITY AND BLOOD LIPID LOWERING ACTIVITY, FOR USE AS AN ANTIDIABETIC AGENT TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-10-12 US disclosed
US-5932601-A USEFUL FOR LOWERING BLOOD SUGAR AND LIPID IN BLOOD TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-08-03 US disclosed
EP-0710659-A1 Oxazolidinedione derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-05-08 EP disclosed