Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 5/20 | 0.77 |
| ▸ | MMP2 | P08253 | 1/20 | 0.77 |
| ▸ | MMP8 | P22894 | 1/20 | 0.77 |
| ▸ | MMP13 | P45452 | 1/20 | 0.77 |
| ▸ | ULK1 | O75385 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6451943 | 0.89 | MMP12 (0.80) | MMP12MMP2MMP8MMP13ULK1 | |
| SCHEMBL6469944 | 0.88 | MMP12 (0.78) | MMP12MMP2MMP8MMP13ULK1 | |
| SCHEMBL6450822 | 0.87 | MMP12 (1.00) | MMP12MMP2MMP8MMP13ULK1 | |
| SCHEMBL6469642 | 0.87 | MMP12 (0.80) | MMP12MMP2MMP8MMP13ULK1 | |
| SCHEMBL8343094 | 0.86 | MMP12 (0.82) | MMP12MMP2MMP8MMP13ULK1 | |
| SCHEMBL6462835 | 0.84 | MMP12 (1.00) | MMP12MMP2MMP8MMP13ULK1 | |
| SCHEMBL6454268 | 0.84 | MMP12 (0.83) | MMP12MMP2MMP8MMP13ULK1 | |
| SCHEMBL6461948 | 0.84 | MMP12 (1.00) | MMP12MMP2MMP8MMP13ULK1 | |
| SCHEMBL6469822 | 0.83 | MMP12 (0.79) | MMP12MMP2MMP8MMP13ULK1 | |
| SCHEMBL6457123 | 0.83 | MMP12 (0.82) | MMP12MMP2MMP8MMP13ULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004018448-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2004-03-04 | — | — | WO | disclosed |