Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 3/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | HTR2C | P28335 | 3/20 | 0.49 |
| ▸ | HTR2B | P41595 | 3/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11594479 | 0.86 | DRD2 (0.66) | DRD3DRD2SIGMAR1HTR2CHTR1A | |
| SCHEMBL19878686 | 0.85 | DRD2 (0.46) | DRD3DRD2SIGMAR1HTR1A | |
| SCHEMBL19878684 | 0.85 | DRD2 (0.46) | DRD3DRD2SIGMAR1HTR1A | |
| SCHEMBL1351856 | 0.84 | DRD2 (0.55) | DRD3DRD2SIGMAR1HTR1AGRIN1 | |
| SCHEMBL3824832 | 0.82 | DRD3 (0.52) | DRD3 | |
| SCHEMBL3824836 | 0.82 | DRD3 (0.52) | DRD3 | |
| SCHEMBL3818836 | 0.82 | HTR2C (0.54) | DRD2SIGMAR1HTR2CHTR2B | |
| SCHEMBL3818838 | 0.82 | HTR2C (0.54) | DRD2SIGMAR1HTR2CHTR2B | |
| SCHEMBL19878791 | 0.81 | HTR2C (0.52) | DRD2SIGMAR1HTR2CHTR2BHTR1A | |
| SCHEMBL19878869 | 0.81 | HTR2C (0.52) | DRD2SIGMAR1HTR2CHTR2BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889010-A | PSYCHOLOGICAL DISORDERS; UROGENITAL DISORDERS; COGNITION ACTIVATORS; NERVOUS SYSTEM DISORDERS; VISION DEFECTS; CONGESTIVE HEART FAILURE; DRUG ABRUSE; PARKINSON'S DISEASE;ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | PFIZER INC. (US) | 1999-03-30 | — | — | US | disclosed |
| EP-0775118-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996004250-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1996-02-15 | — | — | WO | disclosed |