Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 20/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8342747 | 0.93 | ELANE (0.63) | ELANECYP2C9CYP3A4 | |
| SCHEMBL5622517 | 0.92 | ELANE (0.69) | ELANECYP2C9CYP3A4 | |
| SCHEMBL13378025 | 0.92 | ELANE (0.62) | ELANECYP2C9CYP3A4 | |
| SCHEMBL5207894 | 0.85 | ELANE (0.69) | ELANECYP2C9CYP3A4 | |
| SCHEMBL2884242 | 0.85 | ELANE (0.64) | ELANECYP2C9CYP3A4 | |
| SCHEMBL14498476 | 0.84 | ELANE (0.70) | ELANECYP2C9CYP3A4 | |
| SCHEMBL5201924 | 0.84 | ELANE (0.68) | ELANECYP2C9CYP3A4 | |
| SCHEMBL5204844 | 0.82 | ELANE (0.71) | ELANECYP2C9CYP3A4 | |
| SCHEMBL5204213 | 0.81 | ELANE (0.87) | ELANECYP2C9CYP3A4 | |
| SCHEMBL8345249 | 0.81 | ELANE (0.69) | ELANECYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7691854-B2 | Dihydropyridine derivatives for use as human neutrophil elastase inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-04-06 | — | — | US | disclosed |
| US-7691854-B2 | Dihydropyridine derivatives for use as human neutrophil elastase inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-04-06 | — | — | US | disclosed |
| EP-1537081-B1 | DIHYDROPYRIDINE DERIVATIVES FOR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2008-10-15 | — | — | EP | disclosed |
| WO-2004020412-A1 | DIHYDROPYRIDINE DERIVATIVES FOR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2004-03-11 | — | — | WO | disclosed |