Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 20/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14899957 | 0.90 | ELANE (0.60) | ELANECYP2C9 | |
| SCHEMBL2888392 | 0.88 | ELANE (0.77) | ELANECYP2C9 | |
| SCHEMBL2891397 | 0.88 | ELANE (0.78) | ELANECYP2C9 | |
| SCHEMBL2897331 | 0.87 | ELANE (0.77) | ELANECYP2C9 | |
| SCHEMBL8345569 | 0.86 | ELANE (0.75) | ELANECYP2C9 | |
| SCHEMBL8345068 | 0.86 | ELANE (0.72) | ELANECYP2C9 | |
| SCHEMBL13412208 | 0.85 | ELANE (0.74) | ELANECYP2C9 | |
| SCHEMBL8345565 | 0.85 | ELANE (0.73) | ELANECYP2C9 | |
| SCHEMBL13412211 | 0.85 | ELANE (0.73) | ELANECYP2C9 | |
| SCHEMBL13872623 | 0.84 | ELANE (0.72) | ELANECYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687510-B2 | Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes | BAYER HEALTHCARE AG (DE) | 2010-03-30 | — | — | US | disclosed |
| US-7687510-B2 | Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes | BAYER HEALTHCARE AG (DE) | 2010-03-30 | — | — | US | disclosed |
| WO-2004024700-A1 | PYRIMIDINONE DERIVATIVES AS THERAPEUTIC AGENTS AGAINST ACUTE AND CHRONIC INFLAMMATORY, ISCHAEMIC AND REMODELLING PROCESSES | BAYER HEALTHCARE AG (DE) | 2004-03-25 | — | — | WO | disclosed |