Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8344037 | 0.89 | SOAT1 (0.34) | — | |
| SCHEMBL8338963 | 0.87 | EPHX2 (0.34) | TP53MAPTEPHX2 | |
| SCHEMBL8341157 | 0.86 | EPHX2 (0.36) | MAPTEPHX2 | |
| SCHEMBL8343571 | 0.82 | EPHX2 (0.34) | EPHX2 | |
| SCHEMBL8341668 | 0.82 | EPHX2 (0.35) | EPHX2 | |
| SCHEMBL8338151 | 0.81 | EPHX2 (0.36) | EPHX2 | |
| SCHEMBL8343577 | 0.79 | MAPT (0.33) | TP53MAPTKMT2A | |
| SCHEMBL8341369 | 0.79 | EPHX2 (0.34) | EPHX2KMT2A | |
| SCHEMBL8343254 | 0.78 | NPSR1 (0.34) | TP53MAPT | |
| SCHEMBL7771363 | 0.78 | KMT2A (0.39) | TP53MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001860-A | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1999-12-14 | — | — | US | disclosed |
| EP-0642498-A1 | NEW $i(N)-ARYL AND $i(N)-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024458-A1 | NEW N-ARYL AND N-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1993-12-09 | — | — | WO | disclosed |