Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8338963 | 0.99 | EPHX2 (0.34) | EPHX2EPHX1ALDH1A1MAPTKDM4E | |
| SCHEMBL8343577 | 0.91 | MAPT (0.33) | MAPTNPSR1L3MBTL1 | |
| SCHEMBL8343254 | 0.90 | NPSR1 (0.34) | MAPTNPSR1L3MBTL1 | |
| SCHEMBL8341289 | 0.89 | MAPT (0.34) | MAPTNPSR1L3MBTL1 | |
| SCHEMBL7771363 | 0.89 | KMT2A (0.39) | ALDH1A1MAPT | |
| SCHEMBL8344880 | 0.88 | SOAT1 (0.37) | EPHX2ALDH1A1MAPTKDM4E | |
| SCHEMBL8343733 | 0.88 | KMT2A (0.38) | ALDH1A1MAPT | |
| SCHEMBL8338705 | 0.87 | SOAT1 (0.37) | EPHX2ALDH1A1MAPTKDM4E | |
| SCHEMBL8341668 | 0.86 | EPHX2 (0.35) | EPHX2EPHX1 | |
| SCHEMBL8340874 | 0.86 | TP53 (0.31) | EPHX2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001860-A | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1999-12-14 | — | — | US | disclosed |
| EP-0642498-A1 | NEW $i(N)-ARYL AND $i(N)-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024458-A1 | NEW N-ARYL AND N-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1993-12-09 | — | — | WO | disclosed |