Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8345849 | 0.95 | SOAT1 (0.40) | KMT2AMEN1SOAT1ALDH1A1CYP1A2 | |
| SCHEMBL8344016 | 0.89 | KMT2A (0.40) | KMT2AMEN1SOAT1ALDH1A1CYP1A2 | |
| SCHEMBL8344851 | 0.88 | SOAT1 (0.38) | SOAT1ALDH1A1LMNA | |
| SCHEMBL8343733 | 0.88 | KMT2A (0.38) | KMT2AMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8344370 | 0.88 | SOAT1 (0.37) | KMT2AMEN1SOAT1ALDH1A1 | |
| SCHEMBL8338705 | 0.88 | SOAT1 (0.37) | SOAT1ALDH1A1 | |
| SCHEMBL8344880 | 0.87 | SOAT1 (0.37) | SOAT1ALDH1A1 | |
| SCHEMBL7771363 | 0.86 | KMT2A (0.39) | KMT2AMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8345179 | 0.83 | SOAT1 (0.41) | SOAT1 | |
| SCHEMBL8338312 | 0.82 | SOAT1 (0.37) | SOAT1ALDH1A1CYP2C9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001860-A | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1999-12-14 | — | — | US | claimed |
| EP-0642498-A1 | NEW $i(N)-ARYL AND $i(N)-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1995-03-15 | — | — | EP | claimed |
| WO-1993024458-A1 | NEW N-ARYL AND N-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1993-12-09 | — | — | WO | claimed |
| US-6001860-A | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1999-12-14 | — | — | US | disclosed |
| US-5948903-A | Synthesis of 3-deazapurines | ISIS PHARMACEUTICALS, INC. (US) | 1999-09-07 | — | — | US | disclosed |
| EP-0642498-A1 | NEW $i(N)-ARYL AND $i(N)-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024458-A1 | NEW N-ARYL AND N-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1993-12-09 | — | — | WO | disclosed |