Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8340893 | 0.89 | KMT2A (0.39) | KMT2AMEN1SOAT1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8345849 | 0.83 | SOAT1 (0.40) | KMT2AMEN1SOAT1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8343755 | 0.80 | SOAT1 (0.36) | SOAT1ALDH1A1POLBMAPT | |
| SCHEMBL8341134 | 0.78 | SOAT1 (0.39) | SOAT1 | |
| SCHEMBL8340932 | 0.77 | SOAT1 (0.39) | SOAT1 | |
| SCHEMBL8343733 | 0.77 | KMT2A (0.38) | KMT2AMEN1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8339510 | 0.77 | SOAT1 (0.39) | SOAT1 | |
| SCHEMBL8340740 | 0.77 | SOAT1 (0.39) | SOAT1 | |
| SCHEMBL8344851 | 0.76 | SOAT1 (0.38) | SOAT1ALDH1A1LMNAMAPT | |
| SCHEMBL8341460 | 0.76 | SOAT1 (0.40) | SOAT1SMN1; SMN2LMNACYP2C9NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001860-A | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1999-12-14 | — | — | US | disclosed |