⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11392187 | 0.69 | — | — | |
| SCHEMBL3628570 | 0.68 | CYP19A1 (0.43) | — | |
| SCHEMBL11308064 | 0.63 | — | — | |
| SCHEMBL28447016 | 0.63 | TLR4 (0.33) | — | |
| SCHEMBL4619040 | 0.63 | — | — | |
| SCHEMBL900229 | 0.62 | MAPT (0.33) | — | |
| SCHEMBL15209806 | 0.60 | — | — | |
| SCHEMBL1711999 | 0.60 | — | — | |
| Hydrochloric Acid SCHEMBL5239738 | 0.60 | MAPT (0.32) | — | |
| SCHEMBL31310637 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919778-A | Cyclic amide derivatives | EISAI CO., LTD. (JP) | 1999-07-06 | — | — | US | disclosed |
| EP-0677516-B1 | Cyclic amide derivatives | EISAI CO LTD (JP) | 1998-09-02 | — | — | EP | disclosed |
| US-5654308-A | PREVENT OR TREAT DISEASE DUE TO INSUFFICIENT CHOLINE FUNCTION | EISAI CO., LTD. (JP) | 1997-08-05 | — | — | US | disclosed |
| US-5620976-A | PREVENTION AND TREATMENT OF DISEASES DUE TO INSUFFICIENCY OF THE CENTRAL CHOLINE FUNCTIONS | EISAI CO., LTD. (JP) | 1997-04-15 | — | — | US | disclosed |
| EP-0742216-A2 | Cyclic amide derivatives | Eisai Co., Ltd. (JP) | 1996-11-13 | — | — | EP | disclosed |
| US-5521182-A | ACETYLCHOLINESTERASE INHIBITORS | EISAI CO., LTD. (JP) | 1996-05-28 | — | — | US | disclosed |
| US-5504088-A | ACETYLCHOLINE ESTERASE INHIBITORS; ALZHEIMER'S DISEASE AND OTHER DISEASES CAUSED BY A LOW CONCENTRATION OF CHOLINE | EISAI CO., LTD. (JP) | 1996-04-02 | — | — | US | disclosed |
| EP-0677516-A1 | Cyclic amide derivatives | Eisai Co., Ltd. (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-5292735-A | Cyclic amide derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| EP-0468187-A2 | Cyclic amide derivatives | Eisai Co., Ltd. (JP) | 1992-01-29 | — | — | EP | disclosed |