Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | P2RX4 | Q99571 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8343101 | 0.90 | MEN1 (0.48) | KMT2AMEN1SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL8340571 | 0.87 | MEN1 (0.45) | KMT2AMEN1SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL8342841 | 0.81 | KMT2A (0.65) | KMT2AMEN1SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL8341199 | 0.77 | MEN1 (0.64) | KMT2AMEN1SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL27890245 | 0.75 | MEN1 (1.00) | KMT2AMEN1SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL8342494 | 0.71 | LMNA (0.75) | KMT2AMEN1SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL8346200 | 0.71 | MEN1 (0.52) | KMT2AMEN1SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL30434844 | 0.69 | MEN1 (0.53) | KMT2AMEN1SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL15365273 | 0.69 | MEN1 (0.53) | KMT2AMEN1SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL8343102 | 0.68 | MEN1 (0.52) | KMT2AMEN1SMN1; SMN2ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939435-A | TREATMENT OF ATHEROSCLEROSIS AND CORONARY HEART DISEASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-17 | — | — | US | claimed |
| US-5939435-A | TREATMENT OF ATHEROSCLEROSIS AND CORONARY HEART DISEASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-17 | — | — | US | disclosed |