Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL8342087 | 1.00 | PDE4A (0.70) | PDE4ALMNAUSP2SLCO1B1TDP1 | |
| Gluconic Acid SCHEMBL290784 | 0.98 | PDE4A (0.73) | PDE4ALMNAUSP2SLCO1B1TDP1 | |
| Gluconic Acid SCHEMBL27994593 | 0.98 | PDE4A (0.73) | PDE4ALMNAUSP2SLCO1B1TDP1 | |
| Mucic Acid SCHEMBL9324826 | 0.88 | PDE4A (0.54) | PDE4ALMNAUSP2SLCO1B1TSHR | |
| SCHEMBL7217913 | 0.86 | PDE4A (0.95) | PDE4ALMNAUSP2SLCO1B1TDP1 | |
| SCHEMBL9227900 | 0.86 | PDE4A (0.95) | PDE4ALMNAUSP2SLCO1B1TDP1 | |
| SCHEMBL18585384 | 0.86 | PDE4A (0.95) | PDE4ALMNAUSP2SLCO1B1TDP1 | |
| SCHEMBL21580532 | 0.86 | PDE4A (0.95) | PDE4ALMNAUSP2SLCO1B1TDP1 | |
| SCHEMBL6406 | 0.86 | PDE4A (0.95) | PDE4ALMNAUSP2SLCO1B1TDP1 | |
| SCHEMBL10335266 | 0.86 | PDE4A (0.95) | PDE4ALMNAUSP2SLCO1B1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5871577-A | RETARDING SET OF PUMPABLE SLURRY OF HYDRAULIC CEMENT AND WATER BY ADDING ALKANOLAMINE SALT | HALLIBURTON COMPANY (US) | 1999-02-16 | — | — | US | claimed |
| EP-0823408-A1 | Set retarded downhole cementing compositions | Halliburton Energy Services, Inc. (US) | 1998-02-11 | — | — | EP | claimed |
| US-5672203-A | MIXTURE OF HYDRAULIC CEMENT, WATER AND ALKANOLAMINE SALT ADDITIVE IN A PUMPABLE SLURRY, FOR CONSTRUCTING OR REPAIRING SUBTERRANEAN WELLS | HALLIBURTON COMPANY (US) | 1997-09-30 | — | — | US | claimed |