Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8441842 | 0.82 | TSHR (0.68) | TSHRNPSR1LMNAHSD17B10KDM4E | |
| SCHEMBL8438121 | 0.82 | TSHR (0.41) | TSHRNPSR1LMNAHSD17B10KDM4E | |
| SCHEMBL14986931 | 0.81 | TSHR (0.63) | TSHRNPSR1LMNAHSD17B10KDM4E | |
| SCHEMBL11863359 | 0.79 | TSHR (0.67) | TSHRNPSR1LMNAHSD17B10KDM4E | |
| SCHEMBL8345995 | 0.77 | NPSR1 (0.89) | TSHRNPSR1LMNAHSD17B10KDM4E | |
| SCHEMBL8438353 | 0.76 | NPSR1 (0.65) | TSHRNPSR1LMNAHSD17B10KDM4E | |
| SCHEMBL14986928 | 0.76 | TSHR (0.75) | TSHRNPSR1LMNAHSD17B10KDM4E | |
| SCHEMBL9121128 | 0.74 | TSHR (0.71) | TSHRNPSR1LMNAHSD17B10KDM4E | |
| SCHEMBL8165008 | 0.74 | TSHR (0.55) | TSHRNPSR1LMNAHSD17B10KDM4E | |
| SCHEMBL8440699 | 0.73 | NPSR1 (0.57) | TSHRNPSR1LMNAHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942526-A | TREATMENT OF NERVOUS SYSTEM DISORDERS; SELECTIVE POTASSIUM CHANNEL MODULATORS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-08-24 | — | — | US | claimed |
| EP-0717036-B1 | Use of 5-acyl-1,4-dihydropyridines for the treatment of diseases of the CNS | BAYER AG (DE) | 1999-03-17 | — | — | EP | claimed |
| US-5646166-A | POTASSIUM CHANNEL MODULATORS, TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-07-08 | — | — | US | claimed |