Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4438401 | 0.98 | HPGD (0.61) | HPGDNPSR1ALDH1A1MAPTHSD17B10 | |
| SCHEMBL12424630 | 0.83 | POLB (0.74) | HPGDNPSR1ALDH1A1MAPTHSD17B10 | |
| SCHEMBL22089504 | 0.82 | MAPT (0.56) | HPGDNPSR1ALDH1A1MAPTHSD17B10 | |
| SCHEMBL15014074 | 0.80 | NPSR1 (0.64) | HPGDNPSR1ALDH1A1MAPTHSD17B10 | |
| SCHEMBL735675 | 0.80 | TSHR (0.81) | HPGDALDH1A1TSHRPOLBKMT2A | |
| SCHEMBL7239112 | 0.80 | HPGD (0.65) | HPGDNPSR1ALDH1A1MAPTHSD17B10 | |
| SCHEMBL28949192 | 0.80 | HPGD (0.68) | HPGDNPSR1ALDH1A1MAPTHSD17B10 | |
| SCHEMBL12384638 | 0.79 | NPSR1 (0.60) | HPGDNPSR1ALDH1A1MAPTHSD17B10 | |
| SCHEMBL1983277 | 0.78 | HPGD (0.63) | HPGDNPSR1ALDH1A1MAPTHSD17B10 | |
| SCHEMBL13181084 | 0.78 | HDAC3 (0.65) | HPGDNPSR1ALDH1A1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024728-A2 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | disclosed |