Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5541280 | 0.90 | HPGD (0.55) | HPGDTSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL735675 | 0.82 | TSHR (0.81) | HPGDTSHRALDH1A1POLBKMT2A | |
| SCHEMBL28949192 | 0.82 | HPGD (0.68) | HPGDTSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL7239112 | 0.82 | HPGD (0.65) | HPGDTSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL12424630 | 0.82 | POLB (0.74) | HPGDTSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL27857138 | 0.79 | NPSR1 (0.72) | HPGDTSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL15014074 | 0.79 | NPSR1 (0.64) | HPGDTSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL8222746 | 0.79 | HPGD (0.61) | HPGDTSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL4009474 | 0.79 | HPGD (0.61) | HPGDTSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL6738518 | 0.79 | TSHR (0.96) | HPGDTSHRALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509945-A1 | 4- (AZACYCLOALKYL) -BENZENE-1, 3 -DIOL DERIVATIVES AS TYROSINASE INHIBITORS AND THEIR SYNTHESIS AND USE THEREOF | Galderma Research & Development (FR) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011070080-A1 | 4- (AZACYCLOALKYL) -BENZENE-1, 3 -DIOL DERIVATIVES AS TYROSINASE INHIBITORS AND THEIR SYNTHESIS AND USE THEREOF | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-06-16 | — | — | WO | disclosed |