SCHEMBL8342188

SCHEMBL8342188

CC(O)c1ccc(S(=O)(=O)Nc2ccc(C(F)(F)F)c(O[C@@H]3CCN(C)C3)c2)s1

nearest known ligand 0.60

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 17/20 0.60
HTR6 P50406 1/20 0.38
LMNA P02545 1/20 0.36
HTT P42858 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
CNR2 P34972 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6816698 0.89 UTS2R (0.56) UTS2RHTR6LMNAHTTSMN1; SMN2
SCHEMBL6816694 0.89 UTS2R (0.56) UTS2RHTR6LMNAHTTSMN1; SMN2
SCHEMBL8342801 0.87 UTS2R (0.64) UTS2R
SCHEMBL6822827 0.87 UTS2R (0.67) UTS2RLMNAHTTSMN1; SMN2
SCHEMBL6822825 0.87 UTS2R (0.67) UTS2RLMNAHTTSMN1; SMN2
SCHEMBL8342808 0.83 UTS2R (0.61) UTS2RHTR6LMNAHTTSMN1; SMN2
SCHEMBL5745067 0.83 UTS2R (0.70) UTS2R
SCHEMBL6819959 0.83 UTS2R (0.70) UTS2R
SCHEMBL6821445 0.83 UTS2R (0.60) UTS2RHTR6LMNA
SCHEMBL6825889 0.83 UTS2R (0.60) UTS2RHTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043366-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed