Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 5/20 | 0.66 |
| ▸ | PI4K2B | Q8TCG2 | 5/20 | 0.66 |
| ▸ | PI4K2A | Q9BTU6 | 5/20 | 0.66 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.66 |
| ▸ | XDH | P47989 | 2/20 | 0.50 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.46 |
| ▸ | GRM5 | P41594 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23436505 | 0.80 | PI4KA (0.70) | PI4KAPI4K2BPI4K2API4KBXDH | |
| SCHEMBL18292155 | 0.80 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBXDH | |
| SCHEMBL20201240 | 0.76 | PI4KA (0.54) | PI4KAPI4K2BPI4K2API4KBXDH | |
| SCHEMBL5118492 | 0.71 | PI4KA (0.51) | PI4KAPI4K2BPI4K2API4KBGRM1 | |
| SCHEMBL4232868 | 0.69 | EGFR (0.50) | PI4KAPI4K2BPI4K2API4KBXDH | |
| SCHEMBL19350813 | 0.69 | PI4KA (0.62) | PI4KAPI4K2BPI4K2API4KBXDH | |
| SCHEMBL28861601 | 0.68 | PI4KA (0.68) | PI4KAPI4K2BPI4K2API4KBXDH | |
| SCHEMBL30677327 | 0.68 | XDH (0.54) | PI4KAPI4K2BPI4K2API4KBXDH | |
| SCHEMBL23961159 | 0.67 | XDH (0.67) | PI4KAPI4K2BPI4K2API4KBXDH | |
| SCHEMBL5111659 | 0.66 | PI4KA (0.47) | PI4KAPI4K2BPI4K2API4KBGRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |