Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.80 |
| ▸ | MAPT | P10636 | 6/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.80 |
| ▸ | TP53 | P04637 | 5/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.80 |
| ▸ | MEN1 | O00255 | 4/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.80 |
| ▸ | HPGD | P15428 | 3/20 | 0.80 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.80 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.80 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.57 |
| ▸ | NPC1 | O15118 | 9/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 9/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.52 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8343381 | 0.89 | KDM4E (0.94) | KDM4EMAPTALDH1A1TP53KMT2A | |
| SCHEMBL7965438 | 0.89 | KDM4E (1.00) | KDM4EMAPTALDH1A1TP53KMT2A | |
| SCHEMBL8346891 | 0.86 | KDM4E (0.80) | KDM4EMAPTALDH1A1TP53KMT2A | |
| SCHEMBL8343385 | 0.86 | KDM4E (0.80) | KDM4EMAPTALDH1A1TP53KMT2A | |
| SCHEMBL8345592 | 0.83 | ALDH1A1 (0.74) | KDM4EMAPTALDH1A1TP53KMT2A | |
| SCHEMBL8858908 | 0.81 | KDM4E (0.70) | KDM4EMAPTALDH1A1TP53KMT2A | |
| SCHEMBL8346940 | 0.80 | KDM4E (0.58) | KDM4EMAPTALDH1A1TP53KMT2A | |
| SCHEMBL481735 | 0.79 | NPC1 (0.72) | KDM4EMAPTALDH1A1TP53KMT2A | |
| SCHEMBL8343432 | 0.78 | KDM4E (0.74) | KDM4EMAPTALDH1A1TP53KMT2A | |
| SCHEMBL13942807 | 0.78 | NPC1 (0.70) | KDM4EMAPTALDH1A1TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958950-A | CARDIOVASCULAR DISORDERS | WARNER-LAMBERT COMPANY (US) | 1999-09-28 | — | — | US | claimed |
| US-5958950-A | CARDIOVASCULAR DISORDERS | WARNER-LAMBERT COMPANY (US) | 1999-09-28 | — | — | US | disclosed |
| WO-1997012615-A1 | BENZIMIDAZOLE DERIVATIVES AS 15-LO INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1997-04-10 | — | — | WO | disclosed |