Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8585019 | 0.77 | POLB (0.47) | POLBL3MBTL1BRD4BRD2EPHX2 | |
| SCHEMBL13458799 | 0.77 | L3MBTL1 (0.50) | POLBL3MBTL1BRD4BRD2DPP4 | |
| SCHEMBL18978685 | 0.73 | DPP4 (0.41) | DPP4DPP8 | |
| SCHEMBL31323490 | 0.73 | POLB (0.41) | POLBL3MBTL1BRD4BRD2MEN1 | |
| SCHEMBL5350664 | 0.72 | AKR1C3 (0.38) | POLBEPHX2PDK2MEN1KMT2A | |
| SCHEMBL5350661 | 0.72 | AKR1C3 (0.38) | POLBEPHX2PDK2MEN1KMT2A | |
| SCHEMBL5350659 | 0.72 | AKR1C3 (0.38) | POLBEPHX2PDK2MEN1KMT2A | |
| SCHEMBL564317 | 0.71 | POLB (0.63) | POLBL3MBTL1EPHX2PDK2DPP4 | |
| SCHEMBL764061 | 0.71 | POLB (0.63) | POLBL3MBTL1EPHX2PDK2DPP4 | |
| SCHEMBL31206603 | 0.71 | POLB (0.63) | POLBL3MBTL1EPHX2PDK2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999012034-A1 | AMINE COMPOUNDS AND COMBINATORIAL LIBRARIES COMPRISING SAME | ISIS PHARMACEUTICALS, INC. (US) | 1999-03-11 | — | — | WO | disclosed |