Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8338762 | 0.88 | FPR1 (0.34) | LPAR1HTTSOAT1 | |
| SCHEMBL8343999 | 0.85 | SOAT1 (0.38) | TAS1R3TAS1R1LMNACYP2C9SMN1; SMN2 | |
| SCHEMBL8338349 | 0.83 | SOAT1 (0.35) | TAS1R3TAS1R1KMT2ACYP2C9NPSR1 | |
| SCHEMBL8523783 | 0.81 | SOAT1 (0.39) | MEN1KMT2ACYP2C9SMN1; SMN2SOAT1 | |
| SCHEMBL8344420 | 0.81 | KMT2A (0.36) | ALDH1A1LMNACYP1A2MEN1KMT2A | |
| SCHEMBL8340821 | 0.80 | KMT2A (0.36) | ALDH1A1LMNACYP1A2MEN1KMT2A | |
| SCHEMBL8341100 | 0.77 | MEN1 (0.39) | TAS1R3TAS1R1ALDH1A1LMNAMEN1 | |
| SCHEMBL8339156 | 0.76 | SOAT1 (0.38) | TAS1R3TAS1R1CYP2C9SOAT1 | |
| SCHEMBL8341093 | 0.71 | KMT2A (0.37) | ALDH1A1LPAR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7734588 | 0.71 | GRM2 (0.38) | MEN1KMT2AHTTMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001860-A | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1999-12-14 | — | — | US | claimed |
| US-6001860-A | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1999-12-14 | — | — | US | disclosed |
| WO-1993024458-A1 | NEW N-ARYL AND N-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1993-12-09 | — | — | WO | disclosed |