Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 19/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.68 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205336 | 0.93 | ELANE (0.67) | ELANECYP2C9CYP3A4 | |
| SCHEMBL14431993 | 0.93 | ELANE (0.67) | ELANECYP2C9CYP3A4 | |
| SCHEMBL5202163 | 0.92 | ELANE (0.66) | ELANECYP2C9CYP3A4 | |
| SCHEMBL14523472 | 0.91 | ELANE (0.64) | ELANECYP2C9CYP3A4 | |
| SCHEMBL5205126 | 0.91 | ELANE (0.64) | ELANECYP2C9CYP3A4 | |
| SCHEMBL14524154 | 0.89 | ELANE (0.64) | ELANECYP2C9CYP3A4 | |
| SCHEMBL5204800 | 0.89 | ELANE (0.82) | ELANECYP2C9CYP3A4 | |
| SCHEMBL14431508 | 0.88 | ELANE (0.62) | ELANECYP2C9CYP3A4 | |
| SCHEMBL5201907 | 0.87 | ELANE (0.59) | ELANECYP2C9CYP3A4 | |
| SCHEMBL8342471 | 0.87 | ELANE (0.59) | ELANECYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554246-B1 | DIHYDROPYRIDINONE DERIVATIVES AS HNE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2007-08-22 | — | — | EP | disclosed |
| WO-2004020410-A2 | DIHYDROPYRIDINONE DERIVATIVES AS HNE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2004-03-11 | — | — | WO | disclosed |