Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.66 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8338999 | 0.83 | GSK3B (0.61) | GSK3BPIK3CDKDM4EMEN1NPC1 | |
| SCHEMBL8344172 | 0.83 | GSK3B (0.58) | GSK3BPIK3CDKDM4EMEN1NPC1 | |
| SCHEMBL6207166 | 0.82 | GSK3B (0.66) | GSK3BKDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL6251627 | 0.81 | GSK3B (0.66) | GSK3BKDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL8342631 | 0.80 | GSK3B (1.00) | GSK3BGSK3A | |
| SCHEMBL8344397 | 0.78 | GSK3B (0.78) | GSK3BGSK3A | |
| SCHEMBL8342463 | 0.75 | GSK3B (0.75) | GSK3BGSK3A | |
| SCHEMBL6203816 | 0.74 | MAPT (0.68) | GSK3BKDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL6205168 | 0.67 | GSK3B (0.61) | GSK3BPIK3CDMEN1NPC1MAPT | |
| SCHEMBL8339887 | 0.67 | GSK3B (0.62) | GSK3BPIK3CDKDM4EMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |