Dicofol

Dicofol

SCHEMBL8344827

OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)C(Cl)(Cl)Cl.OC(c1ccccc1Cl)(c1ccccc1Cl)C(Cl)(Cl)Cl

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.67
MAPK1 P28482 2/20 0.67
HIF1A Q16665 1/20 0.67
CYP19A1 P11511 7/20 0.51
CYP3A4 P08684 2/20 0.49
CYP3A5 P20815 1/20 0.49
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
KCNN4 O15554 1/20 0.40
LMNA P02545 1/20 0.37
HTT P42858 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
HTR2A P28223 1/20 0.37
HTR2C P28335 1/20 0.37
ADRA1A P35348 1/20 0.37
OPRK1 P41145 1/20 0.37
KCNH2 Q12809 1/20 0.37
ALDH1A1 P00352 1/20 0.36
TDP1 Q9NUW8 1/20 0.35
NR3C1 P04150 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30869981 0.96 TSHR (0.65) TSHRMAPK1HIF1ACYP19A1CYP3A4
SCHEMBL9181207 0.96 TSHR (0.65) TSHRMAPK1HIF1ACYP19A1CYP3A4
SCHEMBL30869980 0.96 TSHR (0.65) TSHRMAPK1HIF1ACYP19A1CYP3A4
SCHEMBL82703 0.88 TSHR (0.44) TSHRMAPK1HIF1ACYP19A1CYP3A4
Dicofol SCHEMBL26640 0.82 TSHR (1.00) TSHRMAPK1HIF1ACYP19A1MEN1
Dicofol SCHEMBL9859511 0.82 TSHR (1.00) TSHRMAPK1HIF1ACYP19A1MEN1
Dicofol SCHEMBL8376564 0.82 TSHR (1.00) TSHRMAPK1HIF1ACYP19A1MEN1
Dicofol SCHEMBL9248379 0.81 HIF1A (0.51) TSHRMAPK1HIF1ACYP19A1CYP3A4
Dicofol SCHEMBL10811113 0.78 TSHR (0.90) TSHRMAPK1HIF1ACYP19A1MEN1
Dicofol SCHEMBL7056043 0.78 TSHR (0.90) TSHRMAPK1HIF1ACYP19A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5952386-A EXCELLENT INSECTICIDAL ACTIVITY FOR THE CONTROL OF NOXIOUS INSECTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-09-14 US disclosed
US-5922880-A CONTROLLING INSECTS, MITES AND TICKS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-07-13 US disclosed
US-5872137-A AROMATIC OXY DIHALOPRENE COMPOUNDS INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-02-16 US disclosed
US-5869506-A APPLYING TO ACARIDS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-02-09 US disclosed