SCHEMBL8344942

SCHEMBL8344942

c1ccc2c(c1)ncn2-c1ccc(-n2cnc3ccccc32)o1

nearest known ligand 0.60

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.60
FGFR1 P11362 3/20 0.58
POLB P06746 1/20 0.55
PIK3CB P42338 1/20 0.47
ROCK1 Q13464 1/20 0.47
MKNK1 Q9BUB5 1/20 0.47
MKNK2 Q9HBH9 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
MAOB P27338 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5564077 0.84 FGFR1 (0.50) HTTFGFR1POLBMAOB
SCHEMBL5564203 0.84 FGFR1 (0.50) HTTFGFR1POLBPIK3CBMKNK1
SCHEMBL29602591 0.79 HTT (0.55) HTTFGFR1POLBPIK3CBROCK1
SCHEMBL6201994 0.78 HTT (0.53) HTTFGFR1POLBPIK3CBROCK1
SCHEMBL6571671 0.78 MAOB (0.52) HTTFGFR1POLBPIK3CBROCK1
SCHEMBL11023857 0.77 FGFR1 (0.57) HTTFGFR1
SCHEMBL30402227 0.77 HTT (0.88) HTTFGFR1POLB
SCHEMBL3417306 0.77 HTT (0.73) HTTFGFR1POLBROCK1MKNK1
SCHEMBL3419279 0.77 HTT (0.88) HTTFGFR1POLB
SCHEMBL9025863 0.75 PIK3CB (0.68) HTTFGFR1POLBPIK3CBROCK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0045279-B1 AMINE OXIDE COMPOUNDS, PROCESSES FOR THEIR MANUFACTURE AND THEIR USE AS OPTICAL BRIGHTENERS CIBA-GEIGY AG (CH) 1988-06-01 EP claimed
EP-0006271-B2 WASHING AND SOFTENING COMPOSITIONS CONTAINING NONIONIC BRIGHTENER THE PROCTER & GAMBLE COMPANY (US) 1986-01-22 EP claimed
EP-0029003-B1 SALTS OF CATIONIC BRIGHTENERS, THEIR PREPARATION AND THEIR USE ON ORGANIC MATERIALS AS WELL AS THEIR CONCENTRATED AQUEOUS SOLUTIONS CIBA-GEIGY AG (CH) 1984-12-05 EP claimed
EP-0006271-B1 WASHING AND SOFTENING COMPOSITIONS CONTAINING NONIONIC BRIGHTENER THE PROCTER & GAMBLE COMPANY (US) 1982-03-31 EP claimed
EP-0045279-A1 Amine oxide compounds, processes for their manufacture and their use as optical brighteners CIBA-GEIGY AG (CH) 1982-02-03 EP claimed
EP-0029003-A2 Salts of cationic brighteners, their preparation and their use on organic materials as well as their concentrated aqueous solutions CIBA-GEIGY AG (CH) 1981-05-20 EP claimed
EP-0006271-A1 Washing and softening compositions containing nonionic brightener THE PROCTER & GAMBLE COMPANY (US) 1980-01-09 EP claimed
WO-1999015608-A1 SOFTENING COMPOSITIONS CONTAINING OPTICAL BRIGHTENERS 3V SIGMA S.P.A. (IT) 1999-04-01 WO disclosed
EP-0045279-B1 AMINE OXIDE COMPOUNDS, PROCESSES FOR THEIR MANUFACTURE AND THEIR USE AS OPTICAL BRIGHTENERS CIBA-GEIGY AG (CH) 1988-06-01 EP disclosed
EP-0006271-B2 WASHING AND SOFTENING COMPOSITIONS CONTAINING NONIONIC BRIGHTENER THE PROCTER & GAMBLE COMPANY (US) 1986-01-22 EP disclosed
US-4539161-A OPTICAL BRIGHTNERS, FLUORESCENT DYES CIBA-GEIGY CORPORATION (US) 1985-09-03 US disclosed
EP-0029003-B1 SALTS OF CATIONIC BRIGHTENERS, THEIR PREPARATION AND THEIR USE ON ORGANIC MATERIALS AS WELL AS THEIR CONCENTRATED AQUEOUS SOLUTIONS CIBA-GEIGY AG (CH) 1984-12-05 EP disclosed
US-4433975-A HETEROCYCLIC QUATERNARY AMMONIUM PHOSPHATES CIBA-GEIGY CORPORATION (US) 1984-02-28 US disclosed
US-4432886-A 2-FURANYLBENZIMIDAZOLE, OR 2-AZOLYLBENZIMIDAZOLE, OR 2-STILBENYLBENZIMIDAZOLE, OR 2,5-(BENZIMIDAZOLYL)FURAN PHOSPHATES CIBA-GEIGY CORPORATION (US) 1984-02-21 US disclosed
US-4384121-A WATER SOLUBLE CIBA-GEIGY CORPORATION (US) 1983-05-17 US disclosed
EP-0006271-B1 WASHING AND SOFTENING COMPOSITIONS CONTAINING NONIONIC BRIGHTENER THE PROCTER & GAMBLE COMPANY (US) 1982-03-31 EP disclosed
EP-0045279-A1 Amine oxide compounds, processes for their manufacture and their use as optical brighteners CIBA-GEIGY AG (CH) 1982-02-03 EP disclosed
EP-0029003-A2 Salts of cationic brighteners, their preparation and their use on organic materials as well as their concentrated aqueous solutions CIBA-GEIGY AG (CH) 1981-05-20 EP disclosed
EP-0006271-A1 Washing and softening compositions containing nonionic brightener THE PROCTER & GAMBLE COMPANY (US) 1980-01-09 EP disclosed