Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 9/20 | 0.60 |
| ▸ | HPRT1 | P00492 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8341140 | 0.98 | PNP (0.59) | PNPHPRT1KDM4ENPSR1DHFR | |
| SCHEMBL8344233 | 0.85 | PNP (0.65) | PNPHPRT1DHFR | |
| Hydrochloric Acid SCHEMBL8345210 | 0.84 | PNP (0.64) | PNPHPRT1DHFR | |
| SCHEMBL8587243 | 0.77 | PNP (0.44) | PNPHPRT1KDM4ENPSR1DHFR | |
| SCHEMBL8344073 | 0.77 | PNP (0.65) | PNPHPRT1 | |
| SCHEMBL10871645 | 0.75 | PNP (0.60) | PNPHPRT1 | |
| Hydrochloric Acid SCHEMBL8341747 | 0.75 | PNP (0.64) | PNPHPRT1 | |
| SCHEMBL12820649 | 0.74 | PNP (0.57) | PNPDHFRXDH | |
| SCHEMBL10872975 | 0.74 | PNP (0.73) | PNPHPRT1 | |
| SCHEMBL5503495 | 0.74 | PNP (0.60) | PNPHPRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5912252-A | Purine and guanine derivatives as PNP inhibitors | DARWIN DISCOVERY LIMITED (GB) | 1999-06-15 | — | — | US | claimed |
| US-5912252-A | Purine and guanine derivatives as PNP inhibitors | DARWIN DISCOVERY LIMITED (GB) | 1999-06-15 | — | — | US | disclosed |