Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.69 |
| ▸ | MC4R | P32245 | 2/20 | 0.66 |
| ▸ | MC5R | P33032 | 1/20 | 0.66 |
| ▸ | MC3R | P41968 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | MPO | P05164 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | CDK4 | P11802 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | NLN | Q9BYT8 | 1/20 | 0.55 |
| ▸ | CCKBR | P32239 | 1/20 | 0.55 |
| ▸ | APAF1 | O14727 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30230046 | 1.00 | TACR1 (0.69) | TACR1MC4RMC5RMC3RKMT2A | |
| SCHEMBL8345144 | 1.00 | TACR1 (0.69) | TACR1MC4RMC5RMC3RKMT2A | |
| SCHEMBL8895238 | 0.87 | TACR1 (0.57) | TACR1MC4RMC5RMC3RKMT2A | |
| SCHEMBL8916109 | 0.85 | TACR1 (0.55) | TACR1MC4RMC5RMC3RKMT2A | |
| SCHEMBL2992113 | 0.85 | KDM4E (0.70) | TACR1MC4RMC5RMC3RKMT2A | |
| SCHEMBL4126005 | 0.85 | KDM4E (0.70) | TACR1MC4RMC5RMC3RKMT2A | |
| SCHEMBL21292830 | 0.85 | KDM4E (0.70) | TACR1MC4RMC5RMC3RKMT2A | |
| SCHEMBL7620106 | 0.84 | CDK4 (0.66) | KMT2ALMNAKDM4EMAPTMEN1 | |
| SCHEMBL8487661 | 0.84 | TACR1 (0.64) | TACR1MC4RMC5RMC3RKMT2A | |
| SCHEMBL1388787 | 0.84 | TACR1 (0.67) | TACR1MC4RMC5RMC3RKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012112945-A1 | USE OF MATRIX METALLOPROTEINASE INHIBITORS TO TREAT TUBERCULOSIS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-08-23 | — | — | WO | disclosed |
| US-5981755-A | Tachykinin antagonists | WARNER-LAMBERT COMPANY (US) | 1999-11-09 | — | — | US | disclosed |
| US-5892112-A | ACYLATION OF AMINO ACIDS WITH ANHYDRIDES OR CARBOXY GROUPS, AMIDATION WITH AMINE AND CONVERSION OF ACID OR ESTER TO HYDROXAMIC ACID AND HYDROLYSIS | GLYCOMED INCORPORATED (US) | 1999-04-06 | — | — | US | disclosed |
| US-5869489-A | TREATMENT OF INFLAMMATORY DISEASES, MIGRAINES AND ASTHMA | MERCK & CO., INC. (US) | 1999-02-09 | — | — | US | disclosed |
| US-5856354-A | RESPIRATORY SYSTEM DISORDERS, ANTIINFLAMMATORY AGENTS, GASTROINTESTINAL DISORDERS, VISION DEFECTS, ANTIALLERGENS,PAIN, NERVOUS SYSTEM DISORDERS, HEADACHES | WARNER-LAMBERT COMPANY (US) | 1999-01-05 | — | — | US | disclosed |
| US-5773438-A | SKIN DISORDERS, RESTENOSIS, RHEUMATIC ARTHRITIS, WOUND HEALING AGENTS, ANGIOGENESIS, SHOCK | GLYCOMED INCORPORATED (US) | 1998-06-30 | — | — | US | disclosed |
| US-5716979-A | NONPEPTIDES, UNIQUE IN ALKYLATION/SUBSTITUTION PATTERN ALONG THEIR BACKBONE, USEFUL FOR TREATING DISORDERS SUCH AS RESPIRATORY, INFLAMMATORY, GASTROINTESTINAL, OPHTHALMIC, ALLERGIES, PAIN, VASCULAR, MIGRANE, ARTHRITIS AND BRAIN | WARNER-LAMBERT COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| US-5594022-A | CARBAMATES | WARNER-LAMBERT COMPANY (US) | 1997-01-14 | — | — | US | disclosed |