Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.66 |
| ▸ | DPP7 | Q9UHL4 | 16/20 | 0.66 |
| ▸ | DPP8 | Q6V1X1 | 15/20 | 0.66 |
| ▸ | DPP9 | Q86TI2 | 8/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4387254 | 0.92 | DPP4 (0.56) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL4550698 | 0.90 | DPP4 (0.61) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL4550697 | 0.90 | DPP4 (0.61) | DPP4DPP7DPP8DPP9 | |
| Hydrochloric Acid SCHEMBL4399414 | 0.89 | DPP4 (0.61) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL4400632 | 0.86 | DPP4 (0.60) | DPP4DPP7DPP8DPP9 | |
| Hydrochloric Acid SCHEMBL4399397 | 0.85 | DPP4 (0.59) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL4391641 | 0.85 | DPP4 (0.60) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL1072764 | 0.85 | DPP4 (0.70) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL1072765 | 0.85 | DPP4 (0.70) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL4390625 | 0.84 | DPP4 (0.69) | DPP4DPP7DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554256-B1 | PIPERIDINO PYRIMIDINE DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES | MERCK & CO INC (US) | 2009-12-09 | — | — | EP | disclosed |
| US-7208498-B2 | Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes | MERCK & CO., INC. (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208498-B2 | Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes | MERCK & CO., INC. (US) | 2007-04-24 | — | — | US | disclosed |
| WO-2004007468-A1 | PIPERIDINO PYRIMIDINE DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES | MERCK & CO., INC. (US) | 2004-01-22 | — | — | WO | disclosed |