SCHEMBL8345236

SCHEMBL8345236

CCOC(=O)CN(C)c1ccc(Cn2cccc(-c3ccc(N)cc3)c2=O)cc1

nearest known ligand 0.42

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ITGB1 P05556 15/20 0.42
ITGA4 P13612 15/20 0.42
PPIB P23284 1/20 0.38
PPIA P62937 1/20 0.38
PPID Q08752 1/20 0.38
PPIG Q13427 1/20 0.38
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
GNRHR P30968 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8345876 0.87 RAB9A (0.43) ITGB1ITGA4ALDH1A1GNRHR
SCHEMBL5069303 0.85 ITGB1 (0.51) ITGB1ITGA4
SCHEMBL5068327 0.81 ITGB1 (0.69) ITGB1ITGA4KDM4E
SCHEMBL14137581 0.79 ITGB1 (0.39) ITGB1ITGA4KDM4EALDH1A1
SCHEMBL8344869 0.78 MAPT (0.39) ITGB1ITGA4KDM4EALDH1A1
SCHEMBL5066936 0.76 ITGB1 (0.52) ITGB1ITGA4
SCHEMBL14096923 0.74 FNTA (0.42) ITGB1ITGA4KDM4EALDH1A1GNRHR
SCHEMBL5069308 0.71 ITGB1 (0.48) ITGB1ITGA4ALDH1A1
SCHEMBL27614661 0.70 ITGB1 (0.53) ITGB1ITGA4
SCHEMBL22537802 0.70 HCRTR2 (0.44) KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7410984-B2 Compounds MITSUBISHI TANABE PHARMA CORPORATION (JP) 2008-08-12 US disclosed
WO-2004014859-A2 PROCESS FOR PREPARING QUINOLIN ANTIBIOTIC INTERMEDIATES TANABE SEIYAKU CO., LTD. (JP) 2004-02-19 WO disclosed