SCHEMBL8345292

SCHEMBL8345292

Cc1cnc2oc(=O)c(C)cc2c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 2/20 0.39
CCR5 P51681 2/20 0.39
CCR8 P51685 2/20 0.39
HSD17B3 P37058 1/20 0.39
CYP1A2 P05177 1/20 0.36
NOS3 P29474 1/20 0.35
NOS1 P29475 1/20 0.35
NOS2 P35228 1/20 0.35
ELANE P08246 5/20 0.35
MAOB P27338 2/20 0.33
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA4 P22748 1/20 0.33
CA6 P23280 1/20 0.33
CA5A P35218 1/20 0.33
CA7 P43166 1/20 0.33
CA9 Q16790 1/20 0.33
CA14 Q9ULX7 1/20 0.33
CA5B Q9Y2D0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7926339 0.76 CCR1 (0.45) CCR1CCR5CCR8CYP1A2NOS3
SCHEMBL28155629 0.74 ALDH1A1 (0.50) CCR1CCR5CCR8CYP1A2ELANE
SCHEMBL28846255 0.73 CCR1 (0.43) CCR1CCR5CCR8HSD17B3CYP1A2
SCHEMBL12317670 0.72 CCR1 (0.45) CCR1CCR5CCR8CYP1A2NOS3
SCHEMBL20721715 0.69 CCR1 (0.38) CCR1CCR5CCR8CYP1A2NOS3
SCHEMBL14542479 0.68 ABL1 (0.34) HSD17B3MAOBCA12CA1CA2
SCHEMBL25748233 0.66 HSD17B3 (0.45) HSD17B3MAOBCA12CA1CA2
SCHEMBL14849034 0.66 NPC1 (0.46) CCR1CCR5CCR8CYP1A2MAOB
SCHEMBL31558612 0.65 MAOB (0.64) HSD17B3MAOBCA12CA1CA2
SCHEMBL8344553 0.65 MAOB (0.64) HSD17B3MAOBCA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004014384-A2 CYCLIC COMPOUNDS CONTAINING ZINC BINDING GROUPS AS MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2004-02-19 WO disclosed