SCHEMBL8345364

SCHEMBL8345364

Nc1ccc([N+](=O)[O-])c2cccnc12

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 14/20 0.67
ALDH1A1 P00352 10/20 0.67
MEN1 O00255 5/20 0.67
KMT2A Q03164 5/20 0.67
SMN1; SMN2 Q16637 4/20 0.67
KDM4E B2RXH2 4/20 0.67
CTSB P07858 3/20 0.67
TDP1 Q9NUW8 3/20 0.67
LMNA P02545 2/20 0.67
HSP90AA1 P07900 2/20 0.67
OPRK1 P41145 2/20 0.67
HTT P42858 2/20 0.67
NPC1 O15118 1/20 0.67
BRD4 O60885 1/20 0.67
CHRM1 P11229 1/20 0.67
DRD2 P14416 1/20 0.67
ALOX12 P18054 1/20 0.67
ADRA2B P18089 1/20 0.67
ADRA2C P18825 1/20 0.67
CHRM3 P20309 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8751507 0.87 MAPT (0.67) MAPTALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL21816802 0.81 MAPT (0.69) MAPTALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL6609076 0.80 ALDH1A1 (0.77) MAPTALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL31731538 0.80 MAPT (0.67) MAPTALDH1A1MEN1KMT2ASMN1; SMN2
Nitroxoline SCHEMBL29363027 0.80 MAPT (1.00) MAPTALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL16066003 0.80 MAPT (0.67) MAPTALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL2246159 0.80 KMT2A (1.00) MAPTALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL2555260 0.80 MAPT (0.67) MAPTALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL3189942 0.80 MAPT (0.67) MAPTALDH1A1MEN1KMT2ASMN1; SMN2
Nitroxoline SCHEMBL151248 0.80 MAPT (1.00) MAPTALDH1A1MEN1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5858613-A COMPRISING RECORDING LAYER CONTAINING AZO METAL COMPLEX DYE; LIGHT RESISTANCE, SENSITIVITY TDK CORPORATION (JP) 1999-01-12 US disclosed
US-5286592-A Electrostatographic toner containing cyan pigment EASTMAN KODAK COMPANY (US) 1994-02-15 US disclosed
EP-0187520-B1 WATER-SOLUBLE DYE IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-01-24 EP disclosed
US-4777248-A Water-soluble non-reactive triazinyl mono-azo dye for ink jet printing IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-10-11 US disclosed
US-4726844-A LIGHTFASTNESS CANON KABUSHIKI KAISHA (JP) 1988-02-23 US disclosed
EP-0187520-A2 Water-soluble dye IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-07-16 EP disclosed
US-4209419-A Certain sulfonamidoquinolines, metal complexes thereof, and solutions containing such sulfonamidoquinolines and metal complexes HENKEL CORPORATION (US) 1980-06-24 US disclosed
US-4100163-A Substituted 8-sulfonamidoquinolines GENERAL MILLS CHEMICALS, INC. (US) 1978-07-11 US disclosed