Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 19/20 | 0.48 |
| ▸ | ACVRL1 | P37023 | 10/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 9/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.43 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.41 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.39 |
| ▸ | BUB1 | O43683 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8345867 | 0.87 | TGFBR1 (0.51) | TGFBR1ACVRL1ACVR1BACVR1BMPR1A | |
| SCHEMBL8344433 | 0.82 | TGFBR1 (0.70) | TGFBR1ACVRL1ACVR1BACVR1BMPR1A | |
| SCHEMBL8347154 | 0.82 | TGFBR1 (0.70) | TGFBR1ACVRL1ACVR1BACVR1BMPR1A | |
| SCHEMBL8344324 | 0.81 | TGFBR1 (0.71) | TGFBR1ACVRL1ACVR1BACVR1BMPR1A | |
| SCHEMBL14223509 | 0.80 | TGFBR1 (0.47) | TGFBR1ACVRL1ACVR1BACVR1BMPR1A | |
| SCHEMBL21177207 | 0.79 | TGFBR1 (0.52) | TGFBR1ACVRL1ACVR1BACVR1BMPR1A | |
| SCHEMBL8348250 | 0.79 | BUB1 (0.46) | TGFBR1PRKD3PRKD1PRKD2TGFBR2 | |
| SCHEMBL5955562 | 0.78 | TGFBR1 (0.58) | TGFBR1ACVRL1ACVR1BACVR1BMPR1A | |
| SCHEMBL16110716 | 0.77 | TGFBR1 (0.73) | TGFBR1ACVRL1ACVR1BACVR1BMPR1A | |
| SCHEMBL5955195 | 0.77 | TGFBR1 (0.62) | TGFBR1ACVRL1ACVR1BACVR1BMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |