SCHEMBL8345774

SCHEMBL8345774

C[C@]12CCC(=O)C([N+](=O)[O-])=C1CC[C@@H]1[C@@H]2CC[C@]2(C)C(OC3CC3)CC[C@@H]12

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SHBG P04278 1/20 0.47
CYP19A1 P11511 11/20 0.42
CYP3A4 P08684 4/20 0.41
TSHR P16473 2/20 0.41
THPO P40225 1/20 0.41
HIF1A Q16665 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
SRD5A2 P31213 2/20 0.41
SRD5A1 P18405 1/20 0.41
NR1I2 O75469 1/20 0.39
LMNA P02545 1/20 0.39
NR3C1 P04150 1/20 0.39
CYP17A1 P05093 1/20 0.39
PGR P06401 1/20 0.39
AR P10275 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
OPRK1 P41145 1/20 0.39
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8339876 1.00 SHBG (0.47) SHBGCYP19A1CYP3A4TSHRTHPO
SCHEMBL8670416 1.00 SHBG (0.47) SHBGCYP19A1CYP3A4TSHRTHPO
SCHEMBL8339872 1.00 SHBG (0.47) SHBGCYP19A1CYP3A4TSHRTHPO
SCHEMBL8340076 0.86 SHBG (0.48) SHBGCYP19A1CYP3A4TSHRTHPO
SCHEMBL8986384 0.84 SHBG (0.67) SHBGCYP19A1CYP3A4TSHRTHPO
SCHEMBL8986390 0.84 SHBG (0.67) SHBGCYP19A1CYP3A4TSHRTHPO
SCHEMBL8339892 0.83 SHBG (0.51) SHBGCYP19A1CYP3A4TSHRTHPO
SCHEMBL8341945 0.83 SHBG (0.69) SHBGCYP19A1CYP3A4TSHRTHPO
SCHEMBL8339888 0.83 SHBG (0.51) SHBGCYP19A1CYP3A4TSHRTHPO
SCHEMBL8341947 0.83 SHBG (0.69) SHBGCYP19A1CYP3A4TSHRTHPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5990328-A FORMING 4-NITRO-3-KETOSTEROIDS WHICH BY NITRATION OF THE CORRESPONDING 3,5-DIENOLATE, REDUCTION OF 4-NITRO-3-KETOSTEROID FORMS 4-AMINO-3-KETOSTEROID MERRELL PHARMACEUTICALS INC. (US) 1999-11-23 US disclosed
US-5965550-A INHIBITING STEROID C17-20 LYASE BY ADMINISTERING A 4-NITRO STEROID INHIBITORY COMPOUND OF GIVEN FORMULA, SUCH AS 17B-CYCLOPROPYLOXY-4-NITROANDROST-4-EN-3-ONE; INHIBITS FORMATION OF BOTH ANDROGENIC AND ESTROGENIC STEROIDS MERRELL PHARMACEUTICALS INC. (US) 1999-10-12 US disclosed
US-5869475-A Certain 3-ketosteroids used to inhibit steroid 5α-reductase MERRELL PHARMACEUTICALS, INC. (US) 1999-02-09 US disclosed
EP-0758340-B1 PROCESS FOR THE PREPARATION OF 4-AMINO-DELTA 4-3-KETOSTEROIDS VIA 4-NITRO-DELTA 4-3-KETOSTEROIDS MERRELL PHARMA INC (US) 1999-01-07 EP disclosed
US-5750744-A ENZYME INHIBITORS MERRELL PHARMACEUTICALS INC. (US) 1998-05-12 US disclosed
EP-0758340-A1 PROCESS FOR THE PREPARATION OF 4-AMINO-DELTA 4-3-KETOSTEROIDS VIA 4-NITRO-DELTA 4-3-KETOSTEROIDS MERRELL PHARMACEUTICALS INC. (US) 1997-02-19 EP disclosed
WO-1995029932-A1 PROCESS FOR THE PREPARATION OF 4-AMINO-Δ4-3-KETOSTEROIDS VIA 4-NITRO-Δ4-3-KETOSTEROIDS MERRELL PHARMACEUTICALS INC. (US) 1995-11-09 WO disclosed