Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | PARG | Q86W56 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8109246 | 0.90 | GRIA1 (0.44) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7354078 | 0.81 | SIRT2 (0.43) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7355341 | 0.81 | GRIN2D (0.63) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8345933 | 0.78 | GRIA1 (0.45) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8121757 | 0.78 | GRIK1 (0.43) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8121197 | 0.78 | GRIK1 (0.45) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8343157 | 0.76 | DAO (0.37) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8107468 | 0.76 | GRIA1 (0.43) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8191455 | 0.76 | GRIA1 (0.53) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8180598 | 0.74 | GRIA1 (0.43) | GRIA1GRIA2GRIA3GRIA4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955461-A | Quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-09-21 | — | — | US | disclosed |
| US-5750525-A | Quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-05-12 | — | — | US | disclosed |