Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 6/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TLR4 | O00206 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3838556 | 0.78 | TGFBR1 (0.47) | PRKD3TGFBR1PRKD1PRKD2PDE4D | |
| SCHEMBL3822929 | 0.78 | TGFBR1 (0.36) | PIM1PRKD3TGFBR1PRKD1PRKD2 | |
| SCHEMBL16424417 | 0.78 | TGFBR1 (0.37) | PRKD3TGFBR1PRKD1PRKD2IDO1 | |
| SCHEMBL3838487 | 0.77 | PDE4D (0.36) | PRKD3TGFBR1PRKD1PRKD2HTR2B | |
| SCHEMBL8344312 | 0.77 | MAPT (0.46) | TGFBR1ALDH1A1KDM4ETDP1 | |
| SCHEMBL8347937 | 0.77 | TGFBR1 (0.36) | PRKD3TGFBR1PRKD1PRKD2PDE4D | |
| SCHEMBL21190043 | 0.76 | TGFBR1 (0.45) | PRKD3TGFBR1PRKD1PRKD2EPHX2 | |
| SCHEMBL8347188 | 0.76 | TGFBR1 (0.43) | PRKD3TGFBR1PRKD1PRKD2IDO1 | |
| SCHEMBL3824986 | 0.75 | MAPT (0.42) | PIM1PRKD3TGFBR1PRKD1PRKD2 | |
| SCHEMBL13649273 | 0.75 | FGFR4 (0.42) | TGFBR1ALDH1A1KDM4EAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |