SCHEMBL8346387

SCHEMBL8346387

CCOC(=N)CCCCC(=O)OCC

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.57
ALDH1A1 P00352 3/20 0.47
ALOX15 P16050 2/20 0.47
TDP1 Q9NUW8 2/20 0.47
CYP3A4 P08684 1/20 0.47
TSHR P16473 1/20 0.47
HSD17B10 Q99714 1/20 0.47
DGKA P23743 1/20 0.47
GAA P10253 2/20 0.46
MGAM O43451 1/20 0.46
SI P14410 1/20 0.46
MGAM2 Q2M2H8 1/20 0.46
NR1I2 O75469 1/20 0.46
PGR P06401 1/20 0.46
ADORA3 P0DMS8 1/20 0.46
PTGS2 P35354 1/20 0.46
PDE4D Q08499 1/20 0.46
CYP4F2 P78329 1/20 0.45
CYP4A11 Q02928 1/20 0.45
KMT2A Q03164 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3041780 0.98 CYP1A2 (0.55) CYP1A2ALDH1A1ALOX15TDP1CYP3A4
SCHEMBL13335171 0.98 CYP1A2 (0.55) CYP1A2ALDH1A1ALOX15TDP1CYP3A4
Hydrochloric Acid SCHEMBL3056090 0.96 CYP1A2 (0.53) CYP1A2ALDH1A1ALOX15TDP1CYP3A4
SCHEMBL9107992 0.86 GAA (0.50) CYP1A2ALDH1A1ALOX15TDP1CYP3A4
SCHEMBL50610 0.86 CYP1A2 (0.73) CYP1A2ALDH1A1ALOX15TDP1CYP3A4
SCHEMBL8570508 0.86 CYP1A2 (0.73) CYP1A2ALDH1A1ALOX15TDP1CYP3A4
SCHEMBL8346390 0.86 ALDH1A1 (0.36) CYP1A2ALDH1A1ALOX15TDP1CYP3A4
SCHEMBL33870 0.84 CYP1A2 (0.70) CYP1A2ALDH1A1ALOX15TDP1CYP3A4
SCHEMBL1483107 0.84 CYP1A2 (0.70) CYP1A2ALDH1A1ALOX15TDP1CYP3A4
SCHEMBL495925 0.84 CYP1A2 (0.70) CYP1A2ALDH1A1ALOX15TDP1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999011701-A1 METHODS OF USING A BUTYLUREA GEL COMPOSITION FOR THE TREATMENT AND PREVENTION OF INFECTIONS ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY, A DIVISION OF YESHIVA UNIVERSITY (US) 1999-03-11 WO claimed
WO-1999011701-A1 METHODS OF USING A BUTYLUREA GEL COMPOSITION FOR THE TREATMENT AND PREVENTION OF INFECTIONS ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY, A DIVISION OF YESHIVA UNIVERSITY (US) 1999-03-11 WO disclosed
US-4115305-A AMIDINE POLYMERS NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1978-09-19 US disclosed