Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.68 |
| ▸ | PREP | P48147 | 2/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | FAP | Q12884 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13909135 | 0.91 | CTSK (0.55) | CTSKPREPDPP4FAPDPP7 | |
| SCHEMBL13909145 | 0.88 | CTSK (0.54) | CTSKPREPDPP4FAPDPP7 | |
| SCHEMBL6209809 | 0.86 | CTSK (0.65) | CTSKALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL13909110 | 0.85 | CTSK (0.56) | CTSKPREPDPP4FAPALDH1A1 | |
| SCHEMBL13909152 | 0.84 | CTSK (0.49) | CTSKPREPDPP4FAPALDH1A1 | |
| SCHEMBL13909154 | 0.84 | CTSK (0.50) | CTSKPREPDPP4FAPALDH1A1 | |
| SCHEMBL8349856 | 0.84 | CTSK (0.62) | CTSKPREPDPP4FAPALDH1A1 | |
| SCHEMBL8349759 | 0.82 | CTSK (0.53) | CTSKPREPDPP4FAPALDH1A1 | |
| SCHEMBL13909222 | 0.82 | PREP (0.56) | CTSKPREPDPP4FAPDPP7 | |
| SCHEMBL4219737 | 0.81 | CTSK (1.00) | CTSKALDH1A1KDM4EGAACTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |