Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16585495 | 0.78 | HTR2C (0.67) | KDM1AMAOAMAOBHTR2CDRD2 | |
| SCHEMBL16585494 | 0.78 | HTR2C (0.67) | KDM1AMAOAMAOBHTR2CDRD2 | |
| SCHEMBL19262122 | 0.78 | HTR2C (0.67) | KDM1AMAOAMAOBHTR2CDRD2 | |
| SCHEMBL17985307 | 0.78 | HTR2C (0.67) | KDM1AMAOAMAOBHTR2CDRD2 | |
| SCHEMBL8939863 | 0.77 | HTR2C (0.49) | KDM1AMAOAMAOBHTR2CMEN1 | |
| SCHEMBL16591168 | 0.76 | KDM1A (0.64) | KDM1AMAOAMAOBHTR2CMEN1 | |
| SCHEMBL18587035 | 0.76 | KMT2A (0.45) | MEN1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18587037 | 0.76 | KMT2A (0.45) | MEN1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27097274 | 0.76 | HTR2C (0.47) | KDM1AMAOAMAOBHTR2CMEN1 | |
| SCHEMBL16747456 | 0.75 | KDM1A (0.47) | KDM1AMAOAMAOBHTR2CTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0693051-B1 | CYCLOPENTENE AND CYCLOPENTANE DERIVATIVES AS ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-11-03 | — | — | EP | disclosed |
| US-5929116-A | VASODILATOR; HYPOTENSIVE AGENT | SMITHKLINE BEECHAM CORPORATION (US) | 1999-07-27 | — | — | US | disclosed |
| WO-1994024084-A1 | CYCLOPENTENE DERIVATIVES AS ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-10-27 | — | — | WO | disclosed |