Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 4/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.43 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NMT2 | O60551 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27097274 | 0.95 | HTR2C (0.47) | HTR2CKDM1AMAOAMAOBHDAC8 | |
| SCHEMBL16585495 | 0.81 | HTR2C (0.67) | HTR2CKDM1AMAOAMAOBSLC5A1 | |
| SCHEMBL17985307 | 0.81 | HTR2C (0.67) | HTR2CKDM1AMAOAMAOBSLC5A1 | |
| SCHEMBL19262122 | 0.81 | HTR2C (0.67) | HTR2CKDM1AMAOAMAOBSLC5A1 | |
| SCHEMBL16585494 | 0.81 | HTR2C (0.67) | HTR2CKDM1AMAOAMAOBSLC5A1 | |
| SCHEMBL10108998 | 0.78 | FFAR1 (0.46) | HTR2CKDM1AMAOAMAOBHDAC8 | |
| SCHEMBL317916 | 0.78 | FFAR1 (0.46) | HTR2CKDM1AMAOAMAOBHDAC8 | |
| SCHEMBL8347367 | 0.77 | KDM1A (0.52) | HTR2CKDM1AMAOAMAOBMEN1 | |
| SCHEMBL31513748 | 0.77 | KDM1A (0.52) | HTR2CKDM1AMAOAMAOBMEN1 | |
| SCHEMBL31513817 | 0.77 | KDM1A (0.52) | HTR2CKDM1AMAOAMAOBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0693051-A4 | CYCLOPENTENE DERIVATIVES AS ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1996-02-28 | — | — | EP | disclosed |
| EP-0693051-A1 | CYCLOPENTENE DERIVATIVES AS ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-01-24 | — | — | EP | disclosed |